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Excited to share Benson’s and Maria’s work in collab w/Kostas Tzelepis: we found the nucleolar protein NPM1 is a marker of AML and can be targeted therapeutically connecting ‘cell surface RNA biology’ to cancer biology @natbiotech.nature.com www.nature.com/articles/s41...

Therapeutic potential of allosteric HECT E3 ligase inhibition www.cell.com/cell/fulltex... "we discover inhibitors that bind a cryptic cavity distant from the catalytic cysteine" ... "these inhibitors restrict an essential catalytic motion by extending an α helix over a conserved glycine hinge"

www.nature.com/articles/s41... "Lipoamide partitions into stress granules in cells, prevents formation of stress granules and dissolves existing stress granules, allowing us to identify a pathway that allows stress granules to sense the oxidative state of the cell."

Broad Target Screening Reveals Abundance of FKBP12-Based Molecular Glues in Focused Libraries pubs.acs.org/doi/10.1021/... "Our results demonstrate that molecular glues are more common than previously thought and that they can be identified by repurposing existing focused libraries."

www.cell.com/cell/abstrac... "Here, we confirm profound diet-PI3K anticancer synergy but show that it is, surprisingly, unrelated to diet macronutrient composition. Instead, the diet-PI3K interaction involves microbiome metabolism of ingested phytochemicals."

Let us take you to the land of sweets with our latest work in @CellChemBiol ! Excited to share this proximity-induced target O-GlcNAc approach, where we uncover transcriptional effects of O-GlcNAc. Congrats to Alison and Dan! 🟦🍭🍬🎵❄️https://sciencedirect.com/science/article/pii/S2451945625003538

Roses are red, GlcNAc is blue, sugar is sweet, and we want YOU to read our latest in @natcomms.nature.com — where we identify small-molecules that disrupt OGlcNAc homeostasis via RNA splicing. Congrats Steven (@scheng23.bsky.social) and all the authors! 🟦🍭❤️ www.nature.com/articles/s41...

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality ...

Competitive (nondegradative) molecular glues represent a promising drug modality that remains underexplored primarily due to the lack of adequate hit identification approaches. In this study, we screened our historically grown FKBP-focused library containing >1000 drug-like molecules to identify FKBP-assisted molecular glues targeting a diverse panel of 57 proteins. In addition to establishing a robust and generalizable screening approach, we discovered three novel FKBP-dependent molecular glues targeting PTPRN, BRD4BD2, and STAT4. Our results demonstrate that molecular glues are more common than previously thought and that they can be identified by repurposing existing focused libraries. An optimized, highly cooperative FKBP12-BRD4BD2 glue demonstrated the involvement of the BD2 pocket and exhibited selectivity over the closely related BD1 domain. Our results underscore the value of FKBP12-assisted molecular glues to target challenging proteins with the potential for high selectivity.

Diet can impact anticancer drug activity. A classic example in rodents is a ketogenic diet enhancing PI3K inhibitor activity. Here, we show that phytochemicals and their microbiome derivatives, rather...

Authors report drug repurposing screens against O-GlcNAc cycling enzymes, finding kinase inhibitors that act as splicing modulators to disrupt O-GlcNAc homeostasis and downregulate OGT and OGA. These ...

Nature Reviews Molecular Cell Biology, Published online: 19 February 2026; doi:10.1038/s41580-026-00955-3In this Tools of the Trade article, Alison Mody (Woo lab) discusses a proximity-induced platform for targeted O-GlcNAcylation of proteins of interest, enabling researchers to measure the effect of O-GlcNAcylation on protein function.

🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...

Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...