www.nature.com/articles/s41...
"Lipoamide partitions into stress granules in cells, prevents formation of stress granules and dissolves existing stress granules, allowing us to identify a pathway that allows stress granules to sense the oxidative state of the cell."
Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...
