Postdoctoral researcher at DTU | Ecology and evolution of antibiotic resistance and infection microbiology of Pseudomonas aeruginosa
Pablo Laborda
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We discuss how the infection environment can shape #AntimicrobialResistance phenotypes, an important but often overlooked factor for predicting antimicrobial efficacy against bacterial pathogens 🦠🧫
#MicroSky
@rug-lrs.bsky.social
The @imili-micro.bsky.social project is such a beautiful and necessary initiative!
I am really glad we could contribute.
Special kudos to PhD student Lilibeth Torres who did the #Klebsiella drawing and wrote the text
- @cbitoulouse.bsky.social
The final version of our latest paper is now published in @natcomms.nature.com!
This study illustrates how #AntibioticResistance mechanisms can reshape bacterial physiology beyond resistance itself, ultimately influencing infection dynamics in clinically relevant ways🦠
www.nature.com/articles/s41...
Unnecessary bureaucracy is a global crisis impeding productivity, advancement of human and planetary wellbeing, science and sustainability. This self-inflicted problem urgently needs solution through global efforts at all levels. doi.org/10.1111/1751...
How does treatment induced antibiotic resistance happen in real-world infections? We analysed 25k Pseudomonas isolates from 180 patients in a clinical trial to find out! TLDR: The ecological and evolutionary paths are surprisingly diverse & complex even in patients receiving identical treatment…
New paper out in PNAS!!! 🎉
Do more plasmid copies mean faster evolution?
🧵 Dive into the story
www.pnas.org/doi/10.1073/...
New preprint!👇
Pyruvate secreted by P. aeruginosa acts as a signaling molecule during infection, reducing oxidative stress, dampening immune activation and promoting persistence
Bacterial metabolism isn’t just a background process but an active player in infection🦠🧫
www.biorxiv.org/content/10.6...
🧵 New preprint! Our 4-lab team evolved Streptococcus pneumoniae in antibiotic-treated mice of varying immune states and discovered something surprising: bacteria rarely evolved resistance. Instead, they found a different way to survive — by rewiring RNA turnover.
🔗 www.biorxiv.org/content/10.6...
The best results come from diverse minds working together. I´m very happy to share a collaborative work between 3 biologists, 2 mathematicians, a physicist, a chemist, and a physician:
www.biorxiv.org/cgi/content/...
@the100footpole.bsky.social @omeuxeito.bsky.social @pablolaborda.bsky.social
Everything you need to explain antimicrobial resistance to family and friends, also in Spanish-10:
@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social
the ESKAPE Rogues
grupos.eez.csic.es/imili/wp-con...
Plasmids are extrachromosomal DNA molecules that spread by horizontal transfer and
shape bacterial evolution. Plasmids are typically present at mul...
Chronic infections by Pseudomonas aeruginosa in people with cystic fibrosis are characterized by persistent inflammation and oxidative stress, yet the mechanisms enabling bacterial persistence are not...
In this work, authors show that the loss of the carbapenem porin OprD in Pseudomonas aeruginosa reduces mucus entrapment and enhances airway epithelial barrier crossing, illustrating how antibiotic re...
International Microbiology Literacy Initiative - IMiLI
Everything you need to explain AMR to family and friends-12:
@pablolaborda.bsky.social
@crisherencias.bsky.social
@pharmageddon.bsky.social
@ecdc.europa.eu
@eberllab.bsky.social
@klebclub.bsky.social
@olayarendueles.bsky.social
the ESKAPE Rogues
www.imili-eah.com/prod-api/pro...
🚨 New pre-print! 🚨 In the largest study of its kind to-date, we investigate the ecological and evolutionary mechanisms driving within-patient evolution of antimicrobial resistance (AMR). Read here:
www.biorxiv.org/content/10.6... , and follow along with this thread, discussing our findings (1/21)
New preprint out! 📣🚨
We found that loss-of-function mutations in the carbapenem entry porin OprD of Pseudomonas aeruginosa do more than confer #AntibioticResistance: they reshape the bacterial membrane and interaction with the host, enhancing epithelial colonization capacity 🦠
#Microsky
Bacterial infections are one of the main challenges that our rapidly developing and growing society will face in the upcoming years. The pipeline for new antibiotic development is drying up, and antimicrobial resistance (AMR) is rising to unprecedented levels. Predictions on deaths attributed to or caused by AMR paint a worrisome picture that cannot be ignored [1]. In response, several initiatives have been launched, from improving current diagnostics to designing new treatments. Artificial intelligence (AI) is currently at the forefront of drug discovery efforts across several diseases.
dlvr.it
www.biorxiv.org
Trends in Microbiology
International Microbiology Literacy Initiative - IMiLI
