Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-026-01451-wBoosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
And forgot to say we made all tools available at @addgene.bsky.social at www.addgene.org/browse/artic... including our new low affinity MitoGCaMP for in vivo fly measurements of mitochondrial Ca2+!
Nature Metabolism
Jaime de Juan-Sanz
Jaime de Juan-Sanz
And fun to ready the commentary by the Misgeld lab - thanks for highlighting our work! www.nature.com/articles/s42...
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-026-01451-wBoosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-026-01451-wBoosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-025-01448-xCalcium entry into mitochondria couples neuronal activity to energy supply, but whether boosting this drive can enhance brain function has remained unclear. Vishwanath et al. now demonstrate that tuning mitochondrial calcium extrusion enhances ATP production and improves cognitive performance in flies and mice, paving the way for a new paradigm of systems neurometabolism.
Exciting new tool for the study of mitochondrial metabolism! Thank you @jdejuan-sanz.bsky.social for sharing your plasmids.
Jaime de Juan-Sanz
Nature Metabolism
Calcium entry into mitochondria couples neuronal activity to energy supply, but whether boosting this drive can enhance brain function has remained unclear. Vishwanath et al. now demonstrate that tuni...
Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
The new Cajal Center is opening 8 CSIC permanent research positions (CT, IC & PF levels) via national competitive exams. We welcome candidates eager to shape an ambitious 🧠research hub in Spain.
đź”— sede.csic.gob.es/tramites/con... đź“Ł
#Neuroscience #CNC #CSIC #ScienceJobs 👇🏼
Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
Jaime de Juan-Sanz
And forgot to say we made all tools available at @addgene.bsky.social at www.addgene.org/browse/artic... including our new low affinity MitoGCaMP for in vivo fly measurements of mitochondrial Ca2+!
sede.csic.gob.es
Jaime de Juan-Sanz
dlvr.it
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-026-01451-wBoosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-026-01451-wBoosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
📢Convocatoria 2026 de 10 plazas para la @academiajoven.bsky.social
➡️Plazo de inscripción abierto hasta el 28 de febrero (improrrogable)
Más información en: academiajoven.es
👉[email protected]
Video
dlvr.it
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-026-01451-wBoosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
