Exciting new tool for the study of mitochondrial metabolism! Thank you @jdejuan-sanz.bsky.social for sharing your plasmids.
And forgot to say we made all tools available at @addgene.bsky.social at www.addgene.org/browse/artic... including our new low affinity MitoGCaMP for in vivo fly measurements of mitochondrial Ca2+!
Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!
Jaime de Juan-Sanz
Addgene
dlvr.it
Nature Metabolism, Published online: 11 February 2026; doi:10.1038/s42255-026-01451-wBoosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.
