Inlay

Nature Metabolism publishes studies that advance our understanding of metabolic and homeostatic processes in physiology and disease. https://www.nature.com/natmetab/

#Throwback 🧪 COMMENT | AI-READI: rethinking AI data collection, preparation and sharing in diabetes research and beyond AI-READI consortium

#Throwback 🧪 REVIEW | GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management Jens J Holst

RESEARCH | Y Zhang, R Zheng, K Chen, YH Tseng et al (Joslin Diabetes Center, US) Beta-adrenergic signalling modulates histone variant H2A.Z deposition, chromatin accessibility and chromatin loop reorganization in mouse and human adipocytes 🧪

#Throwback 🧪 REVIEW | Exploring pancreatic beta-cell subgroups and their connectivity G Rutter, @bennyscience.bsky.social et al

Nature Metabolism, Published online: 09 June 2026; doi:10.1038/s42255-026-01531-xA new drug target for Alzheimer’s disease is highly desired. In a study recently published in Nature Metabolism, Hawkinson, Liu et al. identify a global increase in protein N-glycosylation in Alzheimer’s disease. Worsened pathology due to boosted N-glycosylation from dietary glucosamine uptake suggests that N-glycosylation is a targetable pathway for combating this disease.

Nature Metabolism, Published online: 08 June 2026; doi:10.1038/s42255-026-01541-9Mechanism-based treatments for human illnesses offer superior efficacy and improved tolerability. Here, Ludwig et al. explore the mechanism of action of cagrilintide through single-cell biology and circuit manipulations in the brain to rationalize therapy for obesity.

Here, we introduce Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI), a multidisciplinary data-generation project designed to create and share a multimodal dataset optimized for artificial intelligence research in type 2 diabetes mellitus.

Nature Metabolism, Published online: 03 June 2026; doi:10.1038/s42255-026-01552-6The recent global consensus to rename polycystic ovary syndrome (PCOS) as polyendocrine metabolic ovarian syndrome (PMOS) accurately reframes the condition as a lifelong, multisystemic disorder rather than a localized ovarian pathology. This transition underscores the central role of metabolic dysfunction, specifically the high prevalence of insulin resistance and hyperinsulinaemia, and has important consequences for basic and clinical research.

Beta-adrenergic signalling modulates histone variant H2A.Z deposition, chromatin accessibility and chromatin loop reorganization to regulate thermogenesis in mouse and human adipocytes.

Holst reflects on the development of GLP-1-based drugs for the therapy of obesity, from early observations to remarkable results in more recent clinical trials, discussing physiological, pharmacological and clinical considerations related to their use.

Rutter and Benninger discuss the role of putative controlling beta-cell populations in the context of intra-islet connectivity, how such a cellular hierarchy might be achieved and its potential role in islet physiology and diabetes.

Nature Metabolism, Published online: 09 June 2026; doi:10.1038/s42255-026-01553-5Author Correction: Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy

Nature Metabolism, Published online: 09 June 2026; doi:10.1038/s42255-026-01538-4Through spatial multiomics, spatial stable isotope tracing and retrospective cohort analyses, this study identifies hyperglycosylation as a driver of Alzheimer’s disease and a promising therapeutic target.

Nature Metabolism, Published online: 08 June 2026; doi:10.1038/s42255-026-01539-3To understand which neurons respond to and mediate the action of the amylin receptor agonist cagrilintide, the authors generated a spatially resolved transcriptomics atlas of the caudal brainstem in mice, rats and macaques. Follow-up work in rats identified brainstem Calcr/Prlh neurons as mediators of the long-term effects of cagrilintide.