Cells in crowded epithelia aren’t chosen at random for extrusion & death — energy levels decide who goes. Great work from Jody Rosenblatt and team shows cells with low energy stay depolarized, triggering K⁺ and Cl⁻ channels, lose water, shrink, and are extruded alive. www.nature.com/articles/s41...
Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.
Just flagging up this conference that I'm helping with.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
