Thanks Jon, for sharing our study, which reports a major advance in prostate cancer. This iPROS model overcoming a long-standing barrier of lacking physiologically relevant cancer development models. Importantly, the system models oncogenic plasticity in the presence of BRCA2 genetic-risk variants.
I know right, why don’t you write Fiona’s group at King’s College, they must have it.
Cells in crowded epithelia aren’t chosen at random for extrusion & death — energy levels decide who goes. Great work from Jody Rosenblatt and team shows cells with low energy stay depolarized, triggering K⁺ and Cl⁻ channels, lose water, shrink, and are extruded alive. www.nature.com/articles/s41...