Cells in crowded epithelia aren’t chosen at random for extrusion & death — energy levels decide who goes. Great work from Jody Rosenblatt and team shows cells with low energy stay depolarized, triggering K⁺ and Cl⁻ channels, lose water, shrink, and are extruded alive. www.nature.com/articles/s41...
Just flagging up this conference that I'm helping with.
There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data.
Scan the QR code for full details.
Bipul Acharaya
Jon Humphries
Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.
