šKicking off 2026 with our first paper from the Freudenthal lab in NAR. Ribonucleotides reshape telomeric G4s and are resistant to RNase H2 repair. Congrats to the authors and huge thanks to our collaborator Hui-Ting Lee! academic.oup.com/nar/article/...
This šis such a great opportunity for young scientists in the field. I āgrew upā on this conference & still hold so many meaningful relationships to this day that I made at these conferences.
What does phosphorylation do to RPA?
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...
Great to see our latest study out in NAR Cancer: Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis url: academic.oup.com/narcancer/ar... @weldeiry.bsky.social @emgsus.bsky.social
Great start to 2026! Another successful collaboration with @professorantony.bsky.social lab & final to piece to Dr. Jessica L. Norris's Chemistry PhD thesis with new additions by current Chemistry PhD graduate student Grace Young. Thanks to NIGMS for funding our groups.
doi.org/10.1093/nar/gkaf1478
My lab is currently recruiting 2(!!) postdocs in RNA structural biology/biochemistry! Full details can be found below and on our website (sites.lsa.umich.edu/keane-lab/op...).
The Sfeir Lab at MSKCC is hiring a Research Assistant!
We are looking for a motivated scientist with at least 2 years of research experience and a two-year commitment. Learn more about our work here www.sfeirlab.com, and message me your CV and cover letter if interested
Get ready for a new #EMGS webinar: "Understanding molecular mechanisms of mutagenesis with implications in human health and disease" presented by the Mutagenic Mechanisms and Assessments SIG!
Read More and Register Now! emgs-us.org/event/MolMec...
POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY
We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org
Expertise in structure refinement and model-building are required.
Please share.
academic.oup.com
Abstract. Human telomeres are composed of TTAGGG repeats that can fold into G-quadruplexes (G4s). G4s can form several different conformations, including p
DNA repair genes are generally considered tumor suppressors, as they maintain genomic stability. Here, the authors show that the exonuclease EXO1 is overexpressed in a significant proportion of tumors...
www.nature.com
Abstract. Poly(ADP-ribose) polymerases 1 and 2 (PARP1/PARP2), and poly(ADP-ribose) glycohydrolase (PARG), modulate the level of poly(ADP-ribose) (PAR), a p
š£ The 2026 Midwest DNA Repair Symposium is coming to Kansas City (registration is open)
š May 30ā31, 2026
āØ Talks will be selected from abstracts, with a strong focus on trainees and new investigators.
Please RT & share with your labs!
š sites.google.com/view/kumc-mi...
This was another fun collaboration with @professorantony.bsky.social and big thanks to lead authors (Poonam Roshan, Ayush Mistry and Vikas Kaushi) and to all the co-authors.
www.nature.com/articles/s41...
RPA is an essential ssDNA binding protein. Here, authors uncover a phosphosite on RPA70 and show that the RPA70 and RPA32 subunits cooperate through a phosphocode to reconfigure RPA domains. This sugg...www.nature.com
