What does phosphorylation do to RPA?
This has been a long-standing question in the field of genome integrity.
In our newest publication in Nature Communications rdcu.be/eT4z3 with @proforiganti.bsky.social , we reveal the answer.
Thanks to funding from NIGMS to our groups.
ALT: a man is sitting on a couch with his arms outstretched and making a funny face .
This was another fun collaboration with @professorantony.bsky.social and big thanks to lead authors (Poonam Roshan, Ayush Mistry and Vikas Kaushi) and to all the co-authors.
www.nature.com/articles/s41...
RPA is an essential ssDNA binding protein. Here, authors uncover a phosphosite on RPA70 and show that the RPA70 and RPA32 subunits cooperate through a phosphocode to reconfigure RPA domains. This sugg...
