Lab loves mechanisms-regulation: ribosomes, translation, DNA repair, cell cycle, cancer signaling & dogs! Uplift! opinions-own
Sofi Origanti
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Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.
Sholto David
When nature is messaging to finish up our structural study on ribosomes!
Please share widely. The new (simpler) MIRA R35 for Early Stage Investigators (ESI) NOFO is published. First due date is 10/2/2026. files.simpler.grants.gov/opportunitie...
A dividing cell videoed through a microscope. Hot tip: Don't mess around with myosin II paralogs if you don't want your cells to freak out. #CellBiology
www.cell.com/cell-reports...
Ribosomal allostery as a potential regulator of bacterial dormancy 🦠 www.nature.com/articles/s41...
Sofi Origanti
I-75 Scientist
Video
This is a really important paper in an area that is hard to study. I would recommend any student read this preprint to see how confounding issues arise even in clever assays. Internal Ribosome Entry Sites (IRES) are very interesting because they bypass normal translation initiation mechanisms. 1/
An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org!
www.nature.com/articles/s41...
My PO said I had to fill out this form for 3 of my papers for the RPPR of my NIGMS MIRA grant in February, or I could not include them in my progress report.
It looks like things have gotten even worse since then.
Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dylan Burnette
www.nature.com
Ribosomes are crucial for protein synthesis and managing cellular stress. Here, authors show that ribosomal protein L11 acts as a global regulator, coordinating complex internal signaling to ensure pr...
This Review discusses the expression and maturation of human cytoplasmic tRNAs and recent insights into their regulation of translation. The authors also explore emerging roles of tRNAs in ribosome-as...
Check out our new preprint on IRES studies (www.biorxiv.org/content/10.6...). We show a recently proposed IRES “toolbox” results in mRNA annotation errors and false-positive IRES activities. We provide an alternative set of robust approaches. (1/4)
