Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO www.nature.com/articles/s41... 🦠 cryo-electron microscopy structure of Bacillus subtilis TrhO–tRNAAla complex
Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species. elifesciences.org/articles/107... 🦠
Unconventional monooxygenation by the O2-dependent tRNA wobble uridine hydroxylase TrhO www.nature.com/articles/s41... 🦠 cryo-electron microscopy structure of Bacillus subtilis TrhO–tRNAAla complex
The Escherichia coli Radical SAM Enzyme YhcC Substitutes for the FAD-Dependent Oxidase Activity of MnmC in 5-Methylaminomethyl-2-Thiouridine tRNA Modification Under Anaerobic Conditions www.biorxiv.org/content/10.6... 🦠
🌍 First up: Keynote from Jean-Yves MADEC, One Health Coordinator at Anses-Inserm. He's taking the stage to talk about tackling AMR through a One Health lens — humans, animals, environment, all connected. #OneHealth #AMR
Zeynep Baharoglu
Zeynep Baharoglu
Imane EL MEOUCHE from IAME @inserm.fr is now on stage, diving into how E. coli develops antibiotic tolerance and how cell division plays a role in urinary tract infections. #AMR #UTI
Zeynep Baharoglu
Zeynep Baharoglu
Now at the mic, François-Xavier WEILL from @institutpasteur.bsky.social
He's presenting new findings on the identification and surveillance of a highly drug-resistant strain of Vibrio cholerae O1 El Tor. A global concern. #Cholera #AMR
Second young talent taking the stage: Léo HARDY, Pasteur-Roux-Cantarini fellow from @zeynepbaharoglu.bsky.social lab at IBPC / @pasteur.fr He's diving into the molecular mechanisms by which ribosomal RNA modifications affect antibiotic tolerance.
#AMR #RNA
Christophe D'ENFERT from @institutpasteur.bsky.social and @inrae-france.bsky.social , tackling a too-often overlooked front in the AMR battle — antifungal resistance in pathogenic yeasts. #AMR #Fungi
@ibeidlabex.bsky.social
Now @zeynepbaharoglu.bsky.social from IBPC @cnrs.fr and @pasteur.fr She's exploring how epitranscriptomic regulation controls bacterial response to antibiotics and adaptation to the host. #AMR #RNA
@ibeidlabex.bsky.social
Shin et al. report the cryo-electron microscopy structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a…
www.nature.com
Labex IBEID
Labex IBEID
Labex IBEID
tRNA wobble base uridines are heavily modified to influence anticodon:codon base pairing and tune the structure of the anticodon stem loop for efficient and accurate translation. Both Gram-positive…
Shin et al. report the cryo-electron microscopy structure and catalytic mechanism of TrhO, a cofactor-independent enzyme that hydroxylates tRNA wobble uridine using molecular oxygen through a…
Transcriptome-wide profiling of bacterial RNA pseudouridylation maps modification landscapes and nominates candidate regulatory sites, offering a resource and foundation for future mechanistic…
