Professor of Biochemistry at St. Louis University School of Medicine. Passionate about mechanistic & structural enzymology, electron transfer & nucleic acid binding enzymes. Fascinated by Cryo-EM, kinetics, single molecules and student training. Golf Nut!
Edwin Antony
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www.biorxiv.org/content/10.6...
New research space for the group: RNA binding proteins!
Been chipping away at this for about 3 years now. But, pretty cool to see how a single PTM in an IDR changes overall configurational states of ordered domains.
We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better.
Preprint: www.biorxiv.org/content/10.6...
Code: github.com/warpem/miss-...
🧶 Thread:
If you're interested in the regulation and/or evolution of complex cell behavior, this could serve as an opportunity to join our lab as a postdoc. I would be happy to consult on proposal development if we've got a good alignment of goals, skills, and interests. DMs or emails welcome.
Edwin Antony
Nature Comms is seeking an editor with expertise in clinical infectious diseases urldefense.com/v3/__https:/...
Video
We are looking for Postdoctoral Fellows with expertise in Structural Biology. Expertise in CryoEM/CryoET is required. Come join us in St. Louis to work on some amazing enzyme complexes.
www.antonylab.org/positions.html
APPLY HERE: slu.wd5.myworkdayjobs.com/en-US/Career...
SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out!
www.biorxiv.org/content/10.1...
🚨 Our new paper is out! 🙌
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
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📢🎉@hhmi-science.bsky.social HHMI competition for the next cohorts of #HannaGray Fellows and #FreemanHrabowski Scholars opening 11/3/2026. Senior postdocs and faculty within 7 years of appointment. Up to $10M over 10 yrs, + salary & benefits. Spread the word and consider applying! bit.ly/4vhC0LA
urldefense.com
Leah
New methods article:
David Fay et al integrate endogenous TurboID labeling and data-independent acquisition mass-spectrometry for in vivo proximity labeling
link.springer.com/article/10.1...
A modular strategy combining genetic code expansion with a selective amide bond-forming
reaction enables the site-specific installation of lysine acylations on folded proteins.
Acylboronates react sel...
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Ben Larson
Proximity labeling has emerged as a powerful approach for identifying protein–protein interaction networks within living systems, particularly those involving weak or transient associations. Here, we ...
