🚨 Our new paper is out! 🙌
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
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A modular strategy combining genetic code expansion with a selective amide bond-forming
reaction enables the site-specific installation of lysine acylations on folded proteins.
Acylboronates react sel...
