Prof for chemical biology at ETH Zurich
Interested in: genetic code expansion - chembio tools - bioorthogonal chemistries - PTMs - Ub in all its shades - protein engineering
Kathrin Lang
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📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Are you interested in cutting edge #Biochemistry and #ChemBio?
Check out our #Biochemistry2026 meeting in Würzburg from March 16th to 18th.
Deadlines for reduced early bird registration fee and abstracts have been extended to January 28th.
veranstaltungen.gdch.de/microsite/in...
Max Perutz Labs Vienna
GDCh Division of Biochemistry
The concept:
• GCE installs a reactive handle at a defined site in a protein
• A chemoselective amide bond forming reaction then attaches the desired acyl group
➡️ site-specific protein modification
➡️ compatible with complex/folded proteins
➡️ forms the native amide linkage of lysine acylations
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Why this matters:
Lysine acylations (acetylation, succinylation, etc.) regulate
protein activity, stability and cellular signaling, but accessing homogeneously modified proteins is challenging.
Our approach enables modular installation of diverse lysine acylations at defined sites.
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Super proud of this story! ☺️ Huge thanks to @taruniype.bsky.social for the amazing work - and to @klanglab.bsky.social for the constant support! The first time we saw that phenomenon actually goes all the way back to my Master’s thesis in 2016 🫣 Every now and then, persistence pays off 🤞
Huge congratulations to Pascal, who led this work during his PhD at ETH Zürich, and to Anh, who started with the idea years ago at TU Munich.
🥼🧪🧫🎉🤩
How selective is your favourite electrophile? 🤔 🧪 🧫 🎯
Check out this thorough study from the @stephanhacker2.bsky.social lab, now published in Nature Chemistry!
Many congrats to everyone. We are thrilled to have contributed a little! Many congrats to @klanglab.bsky.social alumni Kristina and Marko!
🚨 Our new paper is out! 🙌
Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
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Kathrin Lang
Kathrin Lang
Kathrin Lang
A modular strategy combining genetic code expansion with a selective amide bond-forming
reaction enables the site-specific installation of lysine acylations on folded proteins.
Acylboronates react sel...
