Thrilled to announce that Alexandra Nusawardhana, graduate student in the lab, was awarded an F31 National Research Service Award fellowship by the NCI to investigate the role of EXO1 in genomic stability. Congratulations Lexi!
Today we said goodbye to Jude and Josh, two outstanding graduate students who joined us in the middle of the pandemic and are now moving on to bigger and better things. Congratulations on your degrees and all the best in the future!
So happy and proud to hood Drs. Lindsey Pale, Jude Khatib and Josh Straka at the 2025 Penn State College of Medicine Commencement ceremony. Congratulations and all the best in your careers!
Congratulations Dr. Straka! Josh successfully defended his PhD thesis today. Wishing him all the best in his future career!
Our year in pictures. Happy holidays everyone!
I meant "translesion synthesis" but autocorrect was quicker than me.
Sharing our latest review on single stranded DNA gaps and their impact on cancer chemotherapy outcomes portlandpress.com/biochemj/art...
Sharing our new paper on the nuclease EXO1. We employed CRISPR genome-wide screening and identified an EXO1 pathway for R-loop suppression doi.org/10.1093/nar/...
Happy to share our new work on the nuclease EXO1, published in Nature Communications. We show that EXO1 is overexpressed in cancers. This promotes nascent DNA degradation, even in BRCA-proficient cells, resulting in genomic instability and chemotherapy sensitization. www.nature.com/articles/s41...
Happy to share our new collaboration paper in Cell Reports. We show that translation synthesis in cancer cells occurs predominantly behind the replication fork, to fill ssDNA gaps, rather than to restart stalled replication forks “on the fly”. www.sciencedirect.com/science/arti...
