Many of you may have received pessimism from me over the years about using Hi-C to predict distal regulatory effects, mired with paradoxical optimism that cohesin loop extrusion is key.
Well, the theoretical story underlying my seemingly paradoxical rambling is finally ready to be told. 👇
Please join us for the next edition of the GOA monthly seminar series Dr Karissa Hansen
Registration link: unimelb.zoom.us/webinar/regi...
📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14
www.biorxiv.org/content/10.6...
Beautiful new study from @elphegenoralab.bsky.social and Leonid Mirny's lab:
Cohesin-bridged encounters mediate enhancer-promoter communication, predicting how enhancer effect scales with genomic distance and - for the first time - how CTCF sites modulate enhancer-promoter communciation!
🧵 below
🚨🧪🧵URGENT INPUT NEEDED: NIH asks input for next strategic plan-including emphasis on non-animal models (NAMs) to replace animals. Per NIH insider, anti-animal responses now outnumber scientists 200-700x. Please please provide input. Deadline: May 26, 11:59 PM ET.
grants.nih.gov/news-events/...
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: Cohesin-mediated loop extrusion and enhancer-associated factors additively contribute to Sox2 looping with its distal enhancer
By Martinovic et al., and Elzo de Wit
➡️ https://ow.ly/H1mH50YWiTO
Elzo de Wit lab @ NKI Netherlands Cancer Institute
#enhancer #cohesin
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬
Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles
By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪
🧵👇
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬
Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles
By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪
🧵👇
