Many of you may have received pessimism from me over the years about using Hi-C to predict distal regulatory effects, mired with paradoxical optimism that cohesin loop extrusion is key.
Well, the theoretical story underlying my seemingly paradoxical rambling is finally ready to be told. 👇
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬
Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles
By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪
🧵👇