Beautiful new study from @elphegenoralab.bsky.social and Leonid Mirny's lab:
Cohesin-bridged encounters mediate enhancer-promoter communication, predicting how enhancer effect scales with genomic distance and - for the first time - how CTCF sites modulate enhancer-promoter communciation!
🧵 below
Luca Giorgetti lab @FMI
Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬
Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles
By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪
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