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Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social

@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk

I am super happy and honored to see some of my movies making it into the NYT. I hope everybody enjoys watching them go as much as I do!

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New method paper out today on FLIM analysis with Flipper-TR. We discuss fitting strategies, common pitfalls, and quantitative interpretation for measurements. First corresponding/last authorship for me! Free link: authors.elsevier.com/a/1me2hHRzCb... Thanks to @rouxlab.bsky.social and Tithi Mandal!

All what you want to know about flipper probes without daring asking

4mo

This monday we had our monthly Sciences Club. Here Cesar Bernat is showing his work on CHMP1A in mammalian cells in the @rouxlab.bsky.social ! #postdoclife

3mo

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Roux Lab, Geneva

thanks for showing this movie! The gradients of tension reorient while migrating cells change directions.

Congrats to Nicolas, Mathieu ad Claire for this important achievement. This will help the community tremendously!

4mo

So grateful to @epimechfc.bsky.social for citing our work! It’s a classic from the lab, forever thanks to @colomlab.bsky.social

Roux Lab, Geneva

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Philipp Radler

You should also read Juanma’s paper, which visualizes membrane tension gradients in migrating and non-migrating cells! rdcu.be/e2u20 It also shows that flipper truly reports tension, but that response varies with lipid composition.

Juanma García-Arcos

Roux Lab, Geneva

4mo

Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social

Roux Lab, Geneva

Association of Postdoc at University of Geneva

Roux Lab, Geneva

4mo

Scientists have seen Asgard archaea crawling for the first time. When it comes to the origin of eukaryotes, this is like seeing a feathered dinosaur in the wild. (Video courtesy of Philipp Ralder)

Roux Lab, Geneva

Nature Communications - This study shows that adherent cells maintain membrane tension gradients even without moving. Using a fluorescent probe, the authors reveal that actin and adhesion forces...

rdcu.be

Adherent cells sustain membrane tension gradients independently of migration

3mo

Mandal, T., Roux, A., & García-Arcos, J. M. (2025). Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM. bioRxiv. #EpithelialMechanics buff.ly/NAytZaR

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Juanma García-Arcos

4mo

Mandal, T., Roux, A., & García-Arcos, J. M. (2025). Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM. bioRxiv. #EpithelialMechanics buff.ly/NAytZaR

4mo

Carl Zimmer

Little reminder about this paper out there, it's a great reference for anyone working on Flipper-TR experiments! By @chloeroffay.bsky.social @rouxlab.bsky.social

Congrats to all authors: @dedenonmathieu.bsky.social, @rouxlab.bsky.social and especially Nicolas Rembert for pushing this project from his internship through his PhD!

4mo

📄 Tension gradients during migration. Using Flipper-TR FLIM, we showed that membrane tension gradients exist in all adherent cells and are actively maintained by actin and adhesion, not passively equilibrating. @rouxlab.bsky.social and Aumeier lab 🔗 bsky.app/profile/epim...