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You should also read Juanma’s paper, which visualizes membrane tension gradients in migrating and non-migrating cells! rdcu.be/e2u20 It also shows that flipper truly reports tension, but that response varies with lipid composition.
4mo
Nature Communications - This study shows that adherent cells maintain membrane tension gradients even without moving. Using a fluorescent probe, the authors reveal that actin and adhesion forces...
rdcu.be
Adherent cells sustain membrane tension gradients independently of migration
Roux Lab, Geneva
Little reminder about this paper out there, it's a great reference for anyone working on Flipper-TR experiments! By @chloeroffay.bsky.social @rouxlab.bsky.social
4mo
Juanma García-Arcos
Roffay, C., García-Arcos, J. M., Chapuis, P., López-Andarias, J., Schneider, F., ...., Roux, A., & Mercier, V. (2024). Tutorial: fluorescence lifetime microscopy of membrane mechanosensitive Flipper probes. Nature protocols, 19(12), 3457–3469. #EpithelialMechanicsReview buff.ly/mTlcVwn
4mo
epithelial mechanics fan club