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A mix of physics and biology, understanding shapes in biology, from molecules to tissues. http://www.orelrouxlab.org

Roux Lab, Geneva

Congrats to Nicolas, Mathieu ad Claire for this important achievement. This will help the community tremendously!

@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk

New method paper out today on FLIM analysis with Flipper-TR. We discuss fitting strategies, common pitfalls, and quantitative interpretation for measurements. First corresponding/last authorship for me! Free link: authors.elsevier.com/a/1me2hHRzCb... Thanks to @rouxlab.bsky.social and Tithi Mandal!

I am super happy and honored to see some of my movies making it into the NYT. I hope everybody enjoys watching them go as much as I do!

Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social

1mo

thanks for showing this movie! The gradients of tension reorient while migrating cells change directions.

All what you want to know about flipper probes without daring asking

This monday we had our monthly Sciences Club. Here Cesar Bernat is showing his work on CHMP1A in mammalian cells in the @rouxlab.bsky.social ! #postdoclife

So grateful to @epimechfc.bsky.social for citing our work! It’s a classic from the lab, forever thanks to @colomlab.bsky.social

You should also read Juanma’s paper, which visualizes membrane tension gradients in migrating and non-migrating cells! rdcu.be/e2u20 It also shows that flipper truly reports tension, but that response varies with lipid composition.

3mo

4mo

3mo

4mo

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Roux Lab, Geneva

Juanma García-Arcos

Philipp Radler

Roux Lab, Geneva

Juanma García-Arcos

Roux Lab, Geneva

Nature Communications - This study shows that adherent cells maintain membrane tension gradients even without moving. Using a fluorescent probe, the authors reveal that actin and adhesion forces...

rdcu.be

Adherent cells sustain membrane tension gradients independently of migration

Association of Postdoc at University of Geneva

Exhaustive guide about Flipper TR FLIM analysis we made with Tithi Mandal and @rouxlab.bsky.social very soon in the methods in Enzymology series edited by @jeremybaskin.bsky.social

Congrats to all authors: @dedenonmathieu.bsky.social, @rouxlab.bsky.social and especially Nicolas Rembert for pushing this project from his internship through his PhD!