Ultrastructure of dopaminergic varicosities revealed by cryo-correlative light and electron microscopy. New study from Matthew Domenic Lycas (@lycasworks.bsky.social), Simon Erlendsson et al. @ucph.bsky.social:
rupress.org/jcb/article/...
#Neuroscience #Organelles #StructuralBiology #cryoCLEM
Got my pictures back
Home microscope project - high NA Phase contrast with the fun Lowa objective
Lomo inverted with the Lomo 1.25 NA water inversion phase contrast
Need to add light source and camera and phase annulus
Expansion microscopy rocks
📢 We're recruiting AI Scientists at HHMI Janelia. I'm biased, but these are exceptional opportunities. You'd join as an independent scientist with access to excellent computational infrastructure, some of the best biological data in the world, and a vibrant collaborative environment.
This mesmerizing timelapse captures the nonstop motion inside an animal cell. Red/orange streaks are the growing ends of microtubules, tiny “highways” that can rapidly assemble and disassemble to move proteins & other molecules within the cell.
📸: Andy Moore, HHMI’s Janelia Research Campus
In @jcb.org, @lycasworks.bsky.social, Erlendsson et al. @ucph.bsky.social develop a #cryoCLEM workflow to characterize the ultrastructure of dopaminergic varicosities. rupress.org/jcb/article/...
#Neuroscience #Organelles #StructuralBiology #Microscopy
My first corresponding author 🔬🎸🦾
rupress.org/jcb/article/...
Ever wonder what the ultrastructure of dopaminergic neuron presynaptic sites looks like? Using cryo-CLEM/ET we observed the wild changes that happen at these sites when the neurons fire or are more quiet.
In the latest @jcb.org
Video
And so it begins! Day 1, Lecture 0 of the first DL for Microscopy Image Analysis course at @hhmijanelia.bsky.social.
Slides from @florianjug.bsky.social, presented by our TA Federico Carrara.
#dljanelia
Lycas et al. develop a cryo-CLEM workflow to characterize the ultrastructure of dopaminergic varicosities. They resolve in situ structures of TRiC/CCT and
