Inlay

ProfileReplies

New study from Pipsa Saharinen’s lab @pipsasaharinen.bsky.social at #WRIHelsinki, featured on the cover of @jci.org: Integrin conformational switching regulates ANGPT2/TIE2/FOXO1 signaling at endothelial cell junctions.👇

Behind the scenes with the Lim lab: Pic 1: Alison Chase and Changwoo (Chris) Lee examining a slide. Pic 2: Changwoo (Chris) Lee, Ben Sanders, Alison Chase, and Janghoo Lim discussing science. Pic 3: Alison Chase, Changwoo Lee, and Janghoo Lim working on transcriptomics and immunohistology.

What integrins in the cell junction are doing without classical extracellular matrix ligands: doi.org/10.1172/JCI1... Sipilä et al. present ANGPT2 in complex with TIE2 and α5β1-integrin via integrative structural biology techniques.

21h

Inactive β1-integrin acts as a junctional scaffold for angiopoietin/TIE2/FOXO1 signaling: doi.org/10.1172/JCI1...

21h

SCA1 is a neurodegenerative disease driven by polyQ expansion in ATXN1 doi.org/10.1172/JCI1... @limlabyale.bsky.social & team provide strong evidence on the role of oligodendrocyte-specific expression of pathogenic ATXN1 in neuronal malfunction and systemic dysfunction in mouse models.

Wihuri Research Institute

CoA regulation is important for its central roles in metabolism, yet most studies have focused on its biosynthesis. doi.org/10.1172/JCI2... Here, Jen-Tsan Chi & team discover the phosphatase MESH1 degrades CoA, increasing vulnerability to oxidative damage and driving muscle loss.

Journal of Clinical Investigation

Behind the scenes with Dr. Kumar Ponna and Tuomas Sipilä, co-first authors, purifying recombinant proteins and discussing a multiprotein model of ANGPT2, α5b1-integrin, and TIE2 ectodomains in the Saharinen lab at the University of Helsinki.

Immune responses in aging adults: doi.org/10.1172/JCI2... In this Review, Cornelia M. Weyand & Jörg J. Goronzy highlight recent advances revealing how immune aging contributes to immune dysregulation and functional decline, as well as to the onset and progression of autoimmune disease.

21h

MESH1-mediated coenzyme A degradation drives ferroptosis sensitivity and muscle pathology: doi.org/10.1172/JCI2...