The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
Journal of Clinical Investigation
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The progression of liver cirrhosis has long been studied, yet the events triggering immune cell recruitment have been unclear
doi.org/10.1172/JCI1...
Gan et al. identify distinct inflammatory niches in liver sinusoidal endothelial cells that amplify pro-inflammatory signaling & fibrosis
Sinusoidal endothelial cells control liver inflammation and fibrosis: doi.org/10.1172/JCI2...
Yingfen Chen and Yong He provide a Commentary on Gan et al. doi.org/10.1172/JCI1...
ICYMI: Reporting on 2 unrelated patients with a rare inborn error affecting CD48: doi.org/10.1172/JCI1...
Milanesi et al. characterize the variants in humans & mice, revealing the importance of CD48 in regulating T-cell responses during infections & in the prevention of excessive inflammation
Presenting a preclinical and translational evaluation of a bispecific antibody–drug conjugate in advanced prostate cancer: doi.org/10.1172/JCI2...
Yao Zhu & team report on a targeted therapy against EGFR & HER3 that delivers a cytotoxic payload and demonstrates effectiveness in mCRPC.
This urine test has the potential to reduce the need for intrusive & costly cystoscopy exams: doi.org/10.1172/JCI2...
Joseph C. Liao & team present a highly sensitive urine biomarker test for the detection & surveillance of bladder cancer with the potential to refine cystoscopy selection
ICYMI: Providing an in vivo model for MPLW515L-positive myeloproliferative neoplasms (MPNs)
doi.org/10.1172/JCI1...
Baobing Zhao & team report a megakaryocyte HSC subpopulation as the disease-initiating compartment, driving essential thrombocythemia‑like MPN that resists JAK inhibitor therapy
Physiological MplW514L expression in hematopoietic stem cell causes an essential thrombocythemia and progressive myelofibrosis: doi.org/10.1172/JCI1...
Epigenetically controlled endothelial promyelocytic leukemia drives liver inflammation and fibrosis
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Large multicenter validation of urine RNA profile for urothelial carcinoma detection and surveillance: doi.org/10.1172/JCI2...
Providing an in vivo model for MPLW515L-positive myeloproliferative neoplasms (MPNs)
doi.org/10.1172/JCI1...
Baobing Zhao & team report a megakaryocyte HSC subpopulation as the disease-initiating compartment, driving essential thrombocythemia‑like MPN that resists JAK inhibitor therapy
