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Epigenetically controlled endothelial promyelocytic leukemia drives liver inflammation and fibrosis
How do cancer stem cells drive brain tumor growth? ASCI member Jeremy N. Rich & team show they produce proline to neutralize oxidative stress and find Tucatinib as a potential drug to disrupt this metabolic shield: doi.org/10.1172/JCI2...
ASCI member Albert R. La Spada & team show cell-free DNA isolated from blood of patients with amyotrophic lateral sclerosis has epigenetic methylation features that can accurately diagnose ALS and potentially predict disease progression: doi.org/10.1172/JCI1...
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Journal of Clinical Investigation
The American Society for Clinical Investigation
The American Society for Clinical Investigation
Associate Professor Jordan Abbott, MD, in our Section of Allergy & Immunology, is co-senior author on this paper.
2d
Providing an in vivo model for MPLW515L-positive myeloproliferative neoplasms (MPNs) doi.org/10.1172/JCI1... Baobing Zhao & team report a megakaryocyte HSC subpopulation as the disease-initiating compartment, driving essential thrombocythemia‑like MPN that resists JAK inhibitor therapy
1d
Of interest to those focused on neurogenetics, lysosomal biology, and neurodegeneration: doi.org/10.1172/JCI1... Dimitri Krainc & team identify BORCS5 variants in cases with a broad spectrum of neurological disorders and reveal a novel role for BORCS5 in lysosomal function.
The progression of liver cirrhosis has long been studied, yet the events triggering immune cell recruitment have been unclear doi.org/10.1172/JCI1... Gan et al. identify distinct inflammatory niches in liver sinusoidal endothelial cells that amplify pro-inflammatory signaling & fibrosis
This urine test has the potential to reduce the need for intrusive & costly cystoscopy exams: doi.org/10.1172/JCI2... Joseph C. Liao & team present a highly sensitive urine biomarker test for the detection & surveillance of bladder cancer with the potential to refine cystoscopy selection
CU Anschutz Department of Pediatrics
23h
3h
2d
Large multicenter validation of urine RNA profile for urothelial carcinoma detection and surveillance: doi.org/10.1172/JCI2...
Physiological MplW514L expression in hematopoietic stem cell causes an essential thrombocythemia and progressive myelofibrosis: doi.org/10.1172/JCI1...
1d
3h
Journal of Clinical Investigation
Journal of Clinical Investigation
Journal of Clinical Investigation
Journal of Clinical Investigation
Journal of Clinical Investigation
Journal of Clinical Investigation
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Variants in human CD48 lead to impaired T-cell immunity and increased inflammation: doi.org/10.1172/JCI1...
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Journal of Clinical Investigation