The interaction between FAM3C and SPIN1 proteins to prevent the lysosomal degradation of SPIN1 and promote the nuclear localization of SPIN1.
The American Society for Clinical Investigation
A strategy that destroys breast cancers in mice: doi.org/10.1172/jci....
ASCI member Eric J. Sorscher & team use ICIs in combination with an E. coli enzyme-based focal gene therapy to enhance tumor clearance and ablate tumor-supporting cells in the microenvironment.
www.jci.org/articles/vie.... Our attempt to take in end-organ dysfunction with the liver as our focus in PAH/RV Failure. @jci.org @natrevgastrohep.nature.com @the-asci.org @mark-toshner.bsky.social
Metabolic reprogramming is critical to microglial activation in Huntington’s disease: doi.org/10.1172/jci....
Kurt
The American Society for Clinical Investigation
📣📣Announcing Frederick Kofi Korley receives the 2026 ASCI/Louis W. Sullivan, MD, Award.
Watch highlights from the interview with Stephen Y. Chan, and view the full conversation on YouTube: youtu.be/nsFj5tUKyEs
How do cancer stem cells drive brain tumor growth?
ASCI member Jeremy N. Rich & team show they produce proline to neutralize oxidative stress and find Tucatinib as a potential drug to disrupt this metabolic shield: doi.org/10.1172/JCI2...
ASCI member Albert R. La Spada & team show cell-free DNA isolated from blood of patients with amyotrophic lateral sclerosis has epigenetic methylation features that can accurately diagnose ALS and potentially predict disease progression: doi.org/10.1172/JCI1...
From improvised to intentional: Re-Imagining the physician-scientist career path: doi.org/10.1172/jci....
ASCI member Kyu Rhee & colleagues discuss the physician-scientist career at its crossroads, drawing from the 2025 ASCI/AAIM/BWF Workshop.
Metformin holds promise in Huntington’s disease: doi.org/10.1172/jci....
ASCI member Robert M. Friedlander & team report metformin regulates mitochondrial fission, reprograms deregulated metabolism in microglia, & controls microglial activation & inflammation in HD mice.
Video
Tucatinib impairs proline biosynthesis and inhibits the proliferation of glioblastoma stem cells.
