From improvised to intentional: Re-Imagining the physician-scientist career path: doi.org/10.1172/jci....
ASCI member Kyu Rhee & colleagues discuss the physician-scientist career at its crossroads, drawing from the 2025 ASCI/AAIM/BWF Workshop.
ASCI member Albert R. La Spada & team show cell-free DNA isolated from blood of patients with amyotrophic lateral sclerosis has epigenetic methylation features that can accurately diagnose ALS and potentially predict disease progression: doi.org/10.1172/JCI1...
Tucatinib impairs proline biosynthesis and inhibits the proliferation of glioblastoma stem cells.
📣📣Announcing Frederick Kofi Korley receives the 2026 ASCI/Louis W. Sullivan, MD, Award.
Watch highlights from the interview with Stephen Y. Chan, and view the full conversation on YouTube: youtu.be/nsFj5tUKyEs
The interaction between FAM3C and SPIN1 proteins to prevent the lysosomal degradation of SPIN1 and promote the nuclear localization of SPIN1.
How do cancer stem cells drive brain tumor growth?
ASCI member Jeremy N. Rich & team show they produce proline to neutralize oxidative stress and find Tucatinib as a potential drug to disrupt this metabolic shield: doi.org/10.1172/JCI2...
Metformin holds promise in Huntington’s disease: doi.org/10.1172/jci....
ASCI member Robert M. Friedlander & team report metformin regulates mitochondrial fission, reprograms deregulated metabolism in microglia, & controls microglial activation & inflammation in HD mice.
www.jci.org/articles/vie.... Our attempt to take in end-organ dysfunction with the liver as our focus in PAH/RV Failure. @jci.org @natrevgastrohep.nature.com @the-asci.org @mark-toshner.bsky.social
Metabolic reprogramming is critical to microglial activation in Huntington’s disease: doi.org/10.1172/jci....
A strategy that destroys breast cancers in mice: doi.org/10.1172/jci....
ASCI member Eric J. Sorscher & team use ICIs in combination with an E. coli enzyme-based focal gene therapy to enhance tumor clearance and ablate tumor-supporting cells in the microenvironment.
