New in #AdvancedScience @wileylifesci.bsky.social : Zhang et al. reveal how ERK, PKA, YAP/TAZ & SHH signaling shape cortical radial glia fateâoffering fresh insight into brain development and evolution. #Neuroscience #RadialGlia #BrainScience #BrainEvolution shorturl.at/Z0isZ
Paulina Strzyz
Ever wondered what a scientific editor actually does? I recently shared my perspective on this in a written interview for the Academic Life Substack:
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#CareersOutsideAcademia #ScientificEditing #AdvancedScience
New in #AdvancedScience @wileylifesci.bsky.social
Human brain #organoids from #Alzheimer's patients now faithfully reproduce disease pathology. Even better: a new #autophagy drug candidate reverses the damage.
A step toward testing treatments in human tissue, not just mice
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#VitaminD does more than support bonesâit fine-tunes sense of #smell! New work in #AdvancedScience @wileylifesci.bsky.social shows vitamin D controls synaptic proteins in the olfactory bulb, using both gene regulation and #mTOR. Nutrition meets #neuroscience!
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#Olfaction
New research in #AdvancedScience @wileylifesci.bsky.social TBK1 phosphorylation drives optineurin to form filaments that phase separate with poly #ubiquitin and LC3, organizing cargo for selective #autophagy. New insight into autophagy and #neurodegeneration.
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New work in #AdvancedScience Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis @ucsantabarbara.bsky.social #Morphogenesis #ECM #Biomaterials #TissueEngineering #CellBiology #Mechanobiology Read full OA article shorturl.at/RxQIh
New review in #AdvancedScience: #Amyloids arenât just disease markersâin bacteria, theyâre dynamic, functional protein assemblies with roles in biofilms, catalysis, and more. Ripe for #biomaterials innovation!
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#microbiology #SyntheticBiology @wileylifesci.bsky.social
New in #AdvancedScience: Dual-humanized mouse model with cryopreserved human lung tissue lets researchers study common cold #coronaviruses & #SARS-CoV-2 in a human-relevant way. Opens doors for testing #antivirals and exploring immune responses.
đ shorturl.at/CYJZU @wileylifesci.bsky.social
New in Advanced Science: BrillouinâRaman microscopy on-a-chip reveals how mechanical stress rewires breast tumor spheroidsâboosting ATF3 and invasion. New tool for cancer mechanobiology.
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#cancer #mechanobiology #biophotonics @wileylifesci.bsky.social @lab-scita.bsky.social
New in #AdvancedScience @wileylifesci.bsky.social
Cells can export the tumor suppressor #p53 in #exosomes and share it with neighbors. The transferred p53 remains functionalâactivating protective programs in recipient cells.
In this way cells might collaborate to prevent cancer.
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The Academic Life newsletter by Christina Gessler, Ph.D.
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A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid-beta and phospho-Tau aggregation, neuronal hyperexcitab...
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor-dependent transcriptional and translational mechanisms. VitD regulates ....
doi.org
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane-anchored LC3 partitions into these condensates, suggesting that...
This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress-relaxing matrices promote branching through focal adhesion signaling, c...
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Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek-key...
Cryopreserved lung-humanized mice overcome the dependency to fresh tissues and permit head-to-head profiling of all four human common cold coronaviruses versus SARS-CoV-2 infection; the model validat...
doi.org
Brillouin-Raman Microspectroscopy on-a-Chip (BRmS) enables real-time analysis of breast tumor spheroids in microfluidic channels. Following cyclical deformations, MCF10.DCIS.com spheroids are capture...
NUMB Ex3-containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells an...
