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New in #AdvancedScience @wileylifesci.bsky.social Human brain #organoids from #Alzheimer's patients now faithfully reproduce disease pathology. Even better: a new #autophagy drug candidate reverses the damage. A step toward testing treatments in human tissue, not just mice 📃https://shorturl.at/HvAKn
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Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid-beta and phospho-Tau aggregation, neuronal hyperexcitab...
advanced.onlinelibrary.wiley.com
Paulina Strzyz