Ever wondered what a scientific editor actually does? I recently shared my perspective on this in a written interview for the Academic Life Substack:
👇
shorturl.at/vqGxU
#CareersOutsideAcademia #ScientificEditing #AdvancedScience
New work in #AdvancedScience Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis @ucsantabarbara.bsky.social #Morphogenesis #ECM #Biomaterials #TissueEngineering #CellBiology #Mechanobiology Read full OA article shorturl.at/RxQIh
New in #AdvancedScience @wileylifesci.bsky.social
Cells can export the tumor suppressor #p53 in #exosomes and share it with neighbors. The transferred p53 remains functional—activating protective programs in recipient cells.
In this way cells might collaborate to prevent cancer.
📄 shorturl.at/veeKj
#VitaminD does more than support bones—it fine-tunes sense of #smell! New work in #AdvancedScience @wileylifesci.bsky.social shows vitamin D controls synaptic proteins in the olfactory bulb, using both gene regulation and #mTOR. Nutrition meets #neuroscience!
🔗 shorturl.at/3ubBn
#Olfaction
New in #AdvancedScience: Dual-humanized mouse model with cryopreserved human lung tissue lets researchers study common cold #coronaviruses & #SARS-CoV-2 in a human-relevant way. Opens doors for testing #antivirals and exploring immune responses.
🔗 shorturl.at/CYJZU @wileylifesci.bsky.social
New in #AdvancedScience @wileylifesci.bsky.social
Human brain #organoids from #Alzheimer's patients now faithfully reproduce disease pathology. Even better: a new #autophagy drug candidate reverses the damage.
A step toward testing treatments in human tissue, not just mice
📃https://shorturl.at/HvAKn
New review in #AdvancedScience: #Amyloids aren’t just disease markers—in bacteria, they’re dynamic, functional protein assemblies with roles in biofilms, catalysis, and more. Ripe for #biomaterials innovation!
🔗 shorturl.at/wPAQb
#microbiology #SyntheticBiology @wileylifesci.bsky.social
New in Advanced Science: Brillouin–Raman microscopy on-a-chip reveals how mechanical stress rewires breast tumor spheroids—boosting ATF3 and invasion. New tool for cancer mechanobiology.
🔗 doi.org/10.1002/advs...
#cancer #mechanobiology #biophotonics @wileylifesci.bsky.social @lab-scita.bsky.social
New in #AdvancedScience @wileylifesci.bsky.social : Zhang et al. reveal how ERK, PKA, YAP/TAZ & SHH signaling shape cortical radial glia fate—offering fresh insight into brain development and evolution. #Neuroscience #RadialGlia #BrainScience #BrainEvolution shorturl.at/Z0isZ
New research in #AdvancedScience @wileylifesci.bsky.social TBK1 phosphorylation drives optineurin to form filaments that phase separate with poly #ubiquitin and LC3, organizing cargo for selective #autophagy. New insight into autophagy and #neurodegeneration.
🔗 shorturl.at/HzkK8
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Paulina Strzyz
Brillouin-Raman Microspectroscopy on-a-Chip (BRmS) enables real-time analysis of breast tumor spheroids in microfluidic channels. Following cyclical deformations, MCF10.DCIS.com spheroids are capture...
This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress-relaxing matrices promote branching through focal adhesion signaling, c...
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid-beta and phospho-Tau aggregation, neuronal hyperexcitab...
advanced.onlinelibrary.wiley.com
NUMB Ex3-containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells an...
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor-dependent transcriptional and translational mechanisms. VitD regulates ....
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek-key...
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane-anchored LC3 partitions into these condensates, suggesting that...
Cryopreserved lung-humanized mice overcome the dependency to fresh tissues and permit head-to-head profiling of all four human common cold coronaviruses versus SARS-CoV-2 infection; the model validat...
