New in #AdvancedScience @wileylifesci.bsky.social
Cells can export the tumor suppressor #p53 in #exosomes and share it with neighbors. The transferred p53 remains functional—activating protective programs in recipient cells.
In this way cells might collaborate to prevent cancer.
📄 shorturl.at/veeKj
NUMB Ex3-containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells an...
