New research in #AdvancedScience @wileylifesci.bsky.social TBK1 phosphorylation drives optineurin to form filaments that phase separate with poly #ubiquitin and LC3, organizing cargo for selective #autophagy. New insight into autophagy and #neurodegeneration.
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Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane-anchored LC3 partitions into these condensates, suggesting that...
