Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1
Antigen-stabilizable fluorescent nanobodies that become fluorescent upon binding intracellular targets enable background-free multicolor imaging and biosensing in living systems. @sdeoliveira.bsky.social
www.nature.com/articles/s41...
A collection of antigen-stabilizable fluorescent nanobodies becomes fluorescent upon binding to their intracellular targets and enables background-free multicolor imaging and biosensing in living syst...
Very excited about our recent preprint- @lindashuyingxu.bsky.social and collabs discover that neutrophils repurpose their nucleolus for storage of pre-made IFN-I to be rapidly released via a nucleolar stress response that results in nucleolar extrusion and secretion.
www.biorxiv.org/content/10.6...
#OTD in 1964, Yvonne Barr co-discovered the Epstein-Barr virus, the first known 𝘩𝘶𝘮𝘢𝘯 tumor virus.
She cultured the cell lines that allowed the virus be seen. Proving viruses cause human cancer is "one of the 20th century's most significant scientific discoveries."
#WomenInSTEM #WomensHistoryMonth
www.biorxiv.org
What would happen if Darwin, Russell Wallace and Koch walked into a bar?
We present our new way to study mycobacteria, employing a macroevolution framework (species not strains). Possibilities are endless!! Thanks to Fernanda Subtil for pushing this.
elifesciences.org/articles/101...
Using macroevolution, species not strains, uncovered important diversity in how mycobacteria respond to and resist antibiotics, revealing novel resistance determinants.
