Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://nej.md/4nWaxvM
#ASCO26
Thrilled to share our new paper out today in @NatureCancer:A single dose of RT makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues. (1/14)
nature.com/articles/s43018-026-01167-6
The Francis Crick Institute
Nils Hebach
Thousands across the UK set to benefit from re-opening of the historic Erasmus+ programme
www.gov.uk
A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based
lung cancer risk reduction and demonstrates how diverse tumor-promoting factors converge
on the induction of an al...
Ahmed and colleagues show that, by promoting ‘dressing’ of intact tumor target antigens onto dendritic cells, tumor irradiation enhances chimeric antigen receptor T cell persistence and efficacy in lu...
How does the nervous system influence cancer ... and vice versa?
Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead.
www.sciencedirect.com/science/arti...
Happy #FluorescenceFriday!
Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation.
More in our recent preprint : www.biorxiv.org/content/10.6...
What if brain metastatic cells do not act alone, but form #networks to help them grow?
In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling.
www.biorxiv.org/content/10.6...
🧵👇
Nils Hebach
Nils Hebach
What if brain metastatic cells do not act alone, but form #networks to help them grow?
In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling.
www.biorxiv.org/content/10.6...
🧵👇
Matthia Karreman
Matthia Karreman
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
