Among patients with previously treated metastatic pancreatic ductal adenocarcinoma, the RAS(ON) inhibitor daraxonrasib led to significantly longer overall survival and progression-free survival than chemotherapy. Full phase 3 RASolute 302 trial results: https://nej.md/4nWaxvM
#ASCO26
Excited to share our ‘Evolutionary characterization of lung cancer metastasis’ in #TRACERx & #PEACE, published today in @nature.com in collaboration with @charlesswanton.bsky.social @nickymcgranahan.bsky.social @zaccasimo.bsky.social at @ucl.ac.uk & @crick.ac.uk. www.nature.com/articles/s41...
The UK rejoining Erasmus is the best science news for a while! #AcademicSky
www.gov.uk/government/n...
Incredible to see our work out today in Cell: "Plasma signals of lung tumor promotion for molecular cancer prevention."
www.cell.com/cell/fulltex...
Thrilled to share our new paper out today in @NatureCancer:A single dose of RT makes CAR T cells work against extensive metastatic lung cancer — even when the target antigen is also on normal tissues. (1/14)
nature.com/articles/s43018-026-01167-6
Researchers at the Crick have uncovered how lung tumours can hijack the activity of nearby nerves to weaken the body’s immune response.
This research was led by Ya-Hsuan Ho and Giacomo Bregni, with corresponding author Leanne Li.
www.crick.ac.uk/news/2026-05...
DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...
www.nature.com
How does the nervous system influence cancer ... and vice versa?
Now online @cp-cell.bsky.social our newest review on current and emerging topics in Cancer Neuroscience 🧠, and many new exciting directions ahead.
www.sciencedirect.com/science/arti...
Thousands across the UK set to benefit from re-opening of the historic Erasmus+ programme
www.gov.uk
A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based
lung cancer risk reduction and demonstrates how diverse tumor-promoting factors converge
on the induction of an al...
Ahmed and colleagues show that, by promoting ‘dressing’ of intact tumor target antigens onto dendritic cells, tumor irradiation enhances chimeric antigen receptor T cell persistence and efficacy in lu...
Our new preprint on calcium signaling in brain metastases is now on bioRxiv!
Thrilled to share the core work of my doctoral thesis in the @winklerlab.bsky.social, together with @nielsolshausen.bsky.social, @matthiakarreman.bsky.social and many more!
Happy #FluorescenceFriday!
Gap junction inhibition disconnects tumour networks in brain metastases and silences Ca²⁺ oscillations that drive proliferation.
More in our recent preprint : www.biorxiv.org/content/10.6...
More details on our main findings in this thread 🧵👇: bsky.app/profile/matt...
William Hill
Jalal
Matthia Karreman
The Francis Crick Institute
Video
Nils Hebach
Nils Hebach
Nils Hebach
What if brain metastatic cells do not act alone, but form #networks to help them grow?
In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling.
www.biorxiv.org/content/10.6...
🧵👇
What if brain metastatic cells do not act alone, but form #networks to help them grow?
In our new #preprint, we show that #brainmetastases form malignant, gap-junction mediated #networks that drive cell cycle progression & neural features through Ca²⁺ signaling.
www.biorxiv.org/content/10.6...
🧵👇
