Now online! AI-generated MLH1 small binder improves prime editing efficiency
#JobOffer
💼 Ingénieur d'étude H/F en biologie moléculaire
📆 1e décembre 2025
📍 Institut Jacques Monod / @mnprioleau.bsky.social
Candidatez sur le portail emploi CNRS avant le 3 octobre 🔗 emploi.cnrs.fr/Offres/CDD/U...
Fantastic work coming out of Neil Hunter’s lab! www.nature.com/articles/s41...
Happy to share our @narjournal.bsky.social paper on the mechanism of Dmc1 filament stabilization by Mei5-Sae3!
We show that Mei5-Sae3 can stabilize both active and inactive Dmc1 filaments, and that this is independent of the ATP hydrolytic cycle.
doi.org/10.1093/nar/...
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
Paper alert! 📢 How do cells strike the perfect balance during meiosis? ⚖️ A new study from the Matos lab in @natureportfolio.nature.com uncovers how Holliday junctions and the synaptonemal complex safeguard crossovers ➡️ tinyurl.com/2k4mmpzu
@univie.ac.at
@meduniwien.ac.at
The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris).
The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at:
minilien.curie.fr/3avv47
A three-year PhD position is available within the team, starting no later than October 2026, to decipher the molecular signatures of chromosomal instability in response to replication stress and how nuclear architecture shapes these signatures in yeast. Please RT.
fr.scribd.com/document/934...
Revised version of our original Red1-Hop1-Mek1 story, together with @jweir.bsky.social lab now online @biorxivpreprint.bsky.social
Check it out: www.biorxiv.org/content/10.1...
Conditional ablation experiments show that key components of the synaptonemal complex protect double Holliday junction recombination intermediates to ensure their resolution into crossover products, which are required for accurate chromosome segregation during meiosis.
The aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...
A compact, AI-generated suppressor of DNA mismatch repair can enhance prime editing in vivo and in vitro and can be integrated into a variety of prime editing architectures.
Meiotic crossover formation is critical for generating viable gametes and enhancing genetic diversity. The helicase Mer3 (HFM1 in humans) is a highly conserved factor essential for promoting crossover...
In mitosis, sister chromatids are preferred repair templates for homologous recombination, whereas in meiosis interhomolog-based repair is promoted. How this switch, which is a defining event in sexua...
Abstract. In budding yeast, Dmc1’s recombinogenic activity is controlled by the meiosis-specific heterodimer Mei5–Sae3. Mei5–Sae3 is required for assembly
