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📣Our paper is out! 🤩 We found that local modification of H3K9me3 using CRISPR/dCas9 at hotspots changes crossover activity, bringing us closer to targeted recombination in plants.🌱 Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina! www.science.org/doi/10.1126/...
Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.
www.science.org
Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in Arabidopsis
3mo
A quick correction: the post below should say H3K4me3, not H3K9me3.👇
Piotr Ziolkowski
📣We’re excited to announce that registration for the Plant Meiosis Meeting is now open‼️ The website and preliminary program are live, and abstract submission will open soon. Book accommodation early due to major trade fairs in Poznań! See you in Poznań! 🌱 pmm.amu.edu.pl
🌿🔍Paper alert‼️ A fantastic study from James Higgins’ group on SCEP3 – a newly identified component of the synaptonemal complex in plants! Happy that our team could be part of this! 😄🧬
📣Plant Meiosis Meeting is back for its second edition‼️ Save the date: 9–11 September 2026, Poznań, Poland🌱 More details coming soon🤩
6mo
⏰ Last week to apply! Don’t miss the chance to join our lab and explore the fascinating world of meiotic recombination 🌿 👉 Deadline: Nov 1, 2025
2mo
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis | Science www.science.org/doi/10.1126/... So cool!!!🤩
🚨 New from our lab in #ScienceAdvances! RAD21L cohesin acts as both a 3D genome architect and a transcriptional gatekeeper in the male germline. Its loss disrupts both structure and function—highlighting the tight link between genome folding and gene regulation www.science.org/doi/10.1126/...
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Piotr Ziolkowski
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
Piotr Ziolkowski
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
www.science.org
Deletion of the meiotic subunit RAD21L alters 3D chromatin structure and transcription in the mammalian male germ line.
www.science.org
Piotr Ziolkowski
Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline
Piotr Ziolkowski
Piotr Ziolkowski
Aurora Ruiz-Herrera
📣Our paper is out! 🤩 We found that local modification of H3K9me3 using CRISPR/dCas9 at hotspots changes crossover activity, bringing us closer to targeted recombination in plants.🌱 Huge thanks to @szymanskalejman.bsky.social, Wojtek, Ania, and Karolina! www.science.org/doi/10.1126/...
Piotr Ziolkowski
3mo
Targeting chromatin modifiers to DNA hotspots reveals causal link between histone marks, transcription, and meiotic recombination.
www.science.org
Modifying meiotic recombination by targeting chromatin regulators to crossover hotspots in Arabidopsis
🚀 We’re hiring a Postdoc! Join our group in Poznan, Poland to study meiotic crossover recombination in plants 🌱 Highly motivated & enthusiastic candidates are welcome! 📅 Deadline: Nov 1, 2025 🔗 ibmib.web.amu.edu.pl/wp-content/uploads/2025/09/Postdoc_position-2025-Ziolkowskis-Lab.pdf
Piotr Ziolkowski
8mo
Piotr Ziolkowski
An early Christmas present from our team for all of the tomato 🍅 & recombination fans: Chromosome-scale Solanum pennellii and Solanum cheesmaniae genome assemblies reveal structural variants, repeat content and recombination barriers of the tomato clade biorxiv.org/content/10.648…
5mo
How do plants control the genes needed for successful sexual reproduction? Our new work uncovers the DREAM complex as a crucial regulator of meiotic recombination in Arabidopsis. Without DREAM, plants are sterile—key recombination genes like MER3 are switched off...