Nature research paper: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
go.nature.com/3RMNwPW
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first.
links.springernature.com/f/a/Q0JMeeZK...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity.
Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it.
Paper: www.nature.com/articles/s41...
Our new smFRET assay to follow intersubunit rotation of eukaryotic ribosomes during translation elongation is out:
academic.oup.com/nar/article/...
CliM is a ribosome arrest peptide in Clostridia. Here, the authors show that CliM adopts helices and extensively interacts with the ribosome. The penultimate residue sterically blocks A-site accommoda...
www.nature.com
The increasing democratization and implementation of electron cryo-microscopy appears poised to drive a new revolution in digital structural biology.
Abstract. Translation is accompanied by the rotation of the small and large ribosomal subunits relative to each other. Here, we use single-molecule Förster
🧪🦠 Streptomyces rimosus
"Das Antibiotikum mit dem Namen Manikomycin wirkt gegen multiresistente Bakterien und könnte langfristig zur Entwicklung neuer Behandlungsoptionen beitragen"
www.welt.de/gesundheit/a...
👇
www.nature.com/articles/s41...
Animalcules
Researchers discover manikomycin, a novel antibiotic that kills drug-resistant bacteria by targeting a previously unknown ribosomal target.
Ausgerechnet ein lange erforschter Mikroorganismus liefert einen bislang unbekannten Wirkstoff gegen multiresistente Keime. Manikomycin ist noch weit von der Klinik entfernt – zeigt aber, wo die Antib...
www.welt.de
🚨 New in @natureportfolio.nature.com! 🚨
Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠
Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance.
Read: doi.org/10.1038/s415...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
