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🚨 New in @natureportfolio.nature.com! 🚨 Excited to share our discovery of Manikomycin—a novel antibiotic tackling the AMR crisis! 🦠 Using cryo-EM, we found it’s the first-in-class to target the ribosomal E-site, blocking tRNA entry and beating multi-drug resistance. Read: doi.org/10.1038/s415...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
doi.org
A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome - Nature
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Haaris Ahsan Safdari