Staff Scientist EM @ MRC LMB, Cambridge 🇬🇧
Single particle cryo-EM, cryo-electron tomography
Haaris Ahsan Safdari
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Nature research paper: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
go.nature.com/3RMNwPW
www.genengnews.com/topics/infec...
www.nature.com/articles/s41...
#microsky
🧪🦠 Streptomyces rimosus
"Das Antibiotikum mit dem Namen Manikomycin wirkt gegen multiresistente Bakterien und könnte langfristig zur Entwicklung neuer Behandlungsoptionen beitragen"
www.welt.de/gesundheit/a...
👇
www.nature.com/articles/s41...
New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity.
Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it.
Paper: www.nature.com/articles/s41...
🚨 New in @natcomms.nature.com 🚨
Excited to share our paper on how proline-rich antimicrobial peptides interact with the bacterial ribosome.
Using cryo-EM, we found that tiny sequence changes cause these peptides to "flip" orientation in the exit tunnel! 🔄🧫
Read: www.nature.com/articles/s41...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
go.nature.com
Researchers discover manikomycin, a novel antibiotic that kills drug-resistant bacteria by targeting a previously unknown ribosomal target.
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
Researchers say they have used a precise genome-editing technique called base editing to alter the genome of human embryos for the first time, an announcement that prompted both excitement and dismay.
go.nature.com/3RUBKD6
Nature
Animalcules
Animalcules
Ausgerechnet ein lange erforschter Mikroorganismus liefert einen bislang unbekannten Wirkstoff gegen multiresistente Keime. Manikomycin ist noch weit von der Klinik entfernt – zeigt aber, wo die Antib...
CliM is a ribosome arrest peptide in Clostridia. Here, the authors show that CliM adopts helices and extensively interacts with the ribosome. The penultimate residue sterically blocks A-site accommoda...
www.nature.com
Gorgias UrUrUrenkel📣🔊
Haaris Ahsan Safdari
In this work authors show how minimal mutations in proline-rich antimicrobial peptides can flip their orientation in the ribosome exit tunnel, switching their mechanism from stalling translation termi...
🔽 (the first) ribosomal E-site targeting antibacterial; producer avoids self-toxicity by rRNA methylation. #Ribosome #AMR
Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM - pubmed.ncbi.nlm.nih.gov/42151144/
Wilson Lab
In this work authors show how minimal mutations in proline-rich antimicrobial peptides can flip their orientation in the ribosome exit tunnel, switching their mechanism from stalling translation termi...
Ribosome arrest peptides undergo programmed translational stalling in response to changes in the cellular environment to feedback-regulate gene expression. CliM, an arrest peptide in Clostridia, is en...
The lead scientist on the use of ‘base editing’ in very early embryos say that the technique is far from ready for the clinic, but critics worry that the work will spur a rush to commercialization.
The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first.
links.springernature.com/f/a/Q0JMeeZK...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
