🔽 (the first) ribosomal E-site targeting antibacterial; producer avoids self-toxicity by rRNA methylation. #Ribosome #AMR
The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first.
links.springernature.com/f/a/Q0JMeeZK...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
