Latest work from PhD student Amna Abbas. One enzyme inactivates three different classes of antibiotics! Yikes. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
By studying the process through which a soil bacterium naturally produces a well-known drug, scientists have discovered a powerful antibiotic that could help to fight drug-resistant infections
go.nature.com/4oyN3wc
The latest from the lab. A new look at an ‘old’ antifungal reveals a novel target with efficacy against MDR fungal pathogens. Nature still has lots to teach us. Great collaboration with the Li, Heitman, and Cowan labs. kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
The latest from the lab. Manikomycin, a new cyclic depsipeptide antibiotic from an 'old' source, the oxytetracycline producer Streptomyces rimosus. Still lots to be learned from this genus! Manikomycin blocks the E-site of the bacterial ribosome. A first.
links.springernature.com/f/a/Q0JMeeZK...
Gerry Wright
They reveal the answer in ACS Infectious Diseases: a single enzyme.
Read more about the enzyme and how this information could lead to a new antibiotic drug candidate for preclinical development: buff.ly/ByYWWe6
@gdwantibiotics.bsky.social [2/2]
Very pleased to announce that Dr. Kirsten Meyer has taken up a faculty position at the University of Waterloo. A very creative scientist with a fascinating diversity of interests ranging from specialized metabolism to drug formulation.
uwaterloo.ca/chemistry/ou...
This is a really cool project, I was lucky to have the opportunity to participate.
news.mcmaster.ca/mcmaster-res...
Happy International Day for Women and Girls in Science! @mcmasteriidr.bsky.social @mcmasternexus.bsky.social @mcmasteruniversity.bsky.social
New paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics! doi.org/10.1371/jour...
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of ...
links.springernature.com
#UofG researchers have identified a natural compound that can disarm drug-resistant bacteria by preventing them from sticking to and spreading within our bodies.
Learn more: uoguel.ph/zltj7
@uofgcbs.bsky.social @uofgresearch.bsky.social
Author summary Type IV pili enable Pseudomonas aeruginosa to attach to surfaces, move (twitch), and form biofilms. Pilus extension is powered by the motor protein PilB, which is regulated by other fac...
