Nature research paper: A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome
go.nature.com/3RMNwPW
Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
