New paper in @natcomms.nature.com! We show how the Clostridia peptide CliM acts as a molecular handbrake to monitor YidC activity.
Cryo-EM & MD show it stalls the ribosome using diverse mechanisms until membrane insertion releases it.
Paper: www.nature.com/articles/s41...
CliM is a ribosome arrest peptide in Clostridia. Here, the authors show that CliM adopts helices and extensively interacts with the ribosome. The penultimate residue sterically blocks A-site accommoda...
