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#CrohnsDisease is associated with NOD2 mutations, but what's NOD2's role in the #intestine? Mckenna Eklund & @edanfoley.bsky.social show that #NOD2 interacts with #estrogen to regulate intestinal homeostasis, perhaps explaining the sex-specific pathogenesis of CD @plosbiology.org 🧪 plos.io/4ojTEuZ

The method to reprogram fully differentiated cells using transcription factors retools cells and has retooled many a scientist’s trajectory. In this article, researchers talk with Nature Methods about this ‘remodeling’ and the future they foresee. #methodsky 🧪

Fehlende genetische Prägung von SARS-CoV-2 begünstigt die Infektion mit BA.3.2.2 bei Kindern »Die stark mutierte Sublinie BA.3.2.2 ist im Gegensatz zu den gleichzeitig auftretenden Varianten XFG und NB.1.8.1 weltweit signifikant häufiger in pädiatrischen Populationen zu finden.

As part of @sfb1638.bsky.social in 𝐌𝐞𝐦𝐛𝐫𝐚𝐧𝐞 𝐑𝐞𝐦𝐨𝐝𝐞𝐥𝐢𝐧𝐠, we are committed to developing computational tools that make complex membrane simulations more accessible, reproducible, and scalable for the scientific community. Today, we are happy to share the public release of 𝐎𝐩𝐞𝐧𝐌𝐞𝐦𝐛𝐫𝐚𝐧𝐞𝐁𝐮𝐢𝐥𝐝𝐞𝐫 v1.2.1

Have you heard of translational bioinformatics? Now you have! 😉 Find out everything you need to know at: https://www.fiosgenomics.com/translational-bioinformatics-advance-your-clinical-research/ #bioinformatics #translationalresearch #clinicalresearch

GBM Lunch on June 17 (12:30 pm) Speaker: Nora Vögtle (@zmbh.uni-heidelberg.de) Title: Sensing and shaping mitochondrial function: Proteolytic control and stress surveillance Chair: Johannes Herrmann (RPTU) Organizer: GBM Study Group "Cellular Organelles" #Mitochondria #GBMLunch #Organelles

Ward, Kar, Balan, and Bhardwaj @bhardwajlab.bsky.social review how conventional type 1 #DendriticCells (cDC1s) coordinate antitumor immunity through cross-presentation, immune cell networking, and spatial organization in tumors. rupress.org/jem/article/... #CancerFocus #Immunotherapy

The method to reprogram fully differentiated cells using transcription factors retools cells — and has retooled many a scientist’s trajectory. Here, researchers comment on this ‘remodeling’ and the future they foresee.

Reactive oxygen species (ROS) function as both damaging and signaling molecules by modifying macromolecules. Advances in proteomics have greatly expanded the identification of ROS target proteins, demonstrating redox modifications as a dominant form of post-translational regulation. However, determining which of these modifications are regulatory and impact protein function remains a key challenge in the field. In this opinion article, we discuss the promise and peril of prioritizing ROS targets identified by proteomics solely based on the highest levels of oxidation for downstream scrutiny. We argue for the integration of functional genomics as a systematic and orthogonal approach for connecting redox-based protein modifications with functional outcomes. This combined approach accelerates the discovery of novel ROS- and other metabolite-modified signaling pathways.