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Nice thread on the importance of spatial structure in microbial communities
Really elegant work showing how spatial distance can determine the net effect of two interaction mechanisms
What a resource!
Imbalance in gut microbial interactions as a marker of health and disease www.science.org/doi/10.1126/...
Cells maintain low metabolite pools to: - enable substrate level regulation - prevent competitive inhibition - avoid side reactions #microsky www.cell.com/cell-systems...
Another example showing how common it is for microbes to release metabolites way beyond what's thought of as waste products Characterization of phytoplankton-excreted metabolites mediating carbon flux through the surface ocean | PNAS www.pnas.org/doi/10.1073/...
Happy to finally share these results: Cross-feeding enables robust coexistence between four bacterial species www.biorxiv.org/content/10.6... With @saramitri.bsky.social @lambdapp.bsky.social @dan1elmachado.bsky.social @lhtxra.bsky.social Eric Ulrich, Alisson Gillon & Sam Testa #microsky
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One of the biggest challenges in microbial biotechnology? Unlocking the potential of non-model microbes and synthetic communities! Glad to share our review @sonjablasche.bsky.social @simonemozzachiodi.bsky.social @kiranrpatil.bsky.social @cambridgebiosci.bsky.social๐Ÿงต(1/7) doi.org/10.1016/j.co...
Check out our pre-print led by the fantastic Massimo Amicone, collaborating with the Bollenbach lab! tinyurl.com/4h9p8mfb We build a simple intuition on how ecological interactions affect resistance evolution by expanding evolutionary rescue theory and testing it with two large sets of experiments
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Snorre Sulheim
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Snorre Sulheim
tinyurl.com
Indra Roux
Rapp et al. combine genome-scale CRISPRi and metabolomics in E. coli. CRISPRi of enzymes enforces metabolite accumulation, which leads to regulatory crosstalk and side reactions. This suggests that ma...
www.cell.com
The metabolome of an E. coli CRISPRi library identifies benefits of minimal metabolite levels and targets for engineering
Imbalances in the human gut microbiome, or dysbioses, are associated with multiple diseases but remain poorly understood. Existing biomarkers of dysbiosis fail to capture the ecological mechanisms tha...
www.science.org
Imbalance in gut microbial interactions as a marker of health and disease
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
In case you missed it: our review titled "Spatial structure: shaping the ecology and evolution of microbial communities" is out! ๐Ÿšจ Let me hit you with some highlights on why spatial structure matters. (and why you should care!) Sharing is appreciated ๐Ÿ™ ๐Ÿงต๐Ÿ‘‡ doi.org/10.1093/fems...
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Bram van Dijk ๐Ÿณ๏ธโ€๐ŸŒˆ
Our Hands On Growth Laws Theory Cookbook is out today! journals.aps.org/prxlife/abst... It covers cell growth models through step-by-step recipes, bridging theory and practical applications, from basic to complex settings. Happy cooking! With @micalilab.bsky.social and @lciandrini.bsky.social
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Excited to share first preprint from our lab! @giubotti.bsky.social found that antibiotic tolerance in multispecies biofilms follows a surprising spatial pattern: cells survive only at intermediate distances from a partner species. ๐Ÿฆ  Preprint: doi.org/10.64898/202...
4mo
Statistical Physics of Cells and Genomes
Simon van Vliet
Sara Mitri