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Cells maintain low metabolite pools to: - enable substrate level regulation - prevent competitive inhibition - avoid side reactions #microsky www.cell.com/cell-systems...
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Rapp et al. combine genome-scale CRISPRi and metabolomics in E. coli. CRISPRi of enzymes enforces metabolite accumulation, which leads to regulatory crosstalk and side reactions. This suggests that ma...
The metabolome of an E. coli CRISPRi library identifies benefits of minimal metabolite levels and targets for engineering
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Snorre Sulheim
