Applications are open for Gates Grand Challenges - funding for projects spanning antibiotic discovery, menstrual bleeding, HIV/TB diagnosis, women’s health, and preeclampsia. Feel free to share. DM me for the email/links.
What is the impact of microplastics on human health? The latest episode of Beyond Journal Club, a collaboration between @coreimpodcast.bsky.social and NEJM Group, takes a deep dive into the APAChE study on microplastics and cardiovascular disease. 🎧 Listen here: nej.md/4igpJQy
#MedSky
Excited to share this work from the Garcia Lab out today in @naturecomms.bsky.social! We engineer "cytokine adaptors", molecular immune switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors. rdcu.be/ec7GS
Conversely, we show that cytokine adaptors can convert inflammatory cytokines into immunosuppressive signals. We show conversion of IL-23 or IL-17 into immunosuppressive IL-10 receptor agonists, with potential applications in autoimmune disease.
To reroute a cytokine’s signaling, Abhiraman et al. generated soluble adaptors comprising units that bind to two sites on a cytokine linked to units that bind to and compel dimerization/activation [...] bit.ly/4l0nd2G @stanfordmedicine.bsky.social @gitaabhiraman.bsky.social
Many thanks to Chris Garcia, Karsten Householder, @graysonrodriguez.bsky.social, Caleb Glassman, Robert Saxton, our collaborators @retickerflynn.bsky.social, Cort Breuer, Venu Pillarisetty at UW, and several others in the Garcia lab who contributed to this work!
As proof of concept, we design cytokine adaptors that convert TGF-b or IL-10 into IL-2 receptor agonists to reverse T cell suppression, with potential applications in cancer therapy.
A crowd-sourced list of changes to grad school admissions and academic hiring: docs.google.com/spreadsheets...